5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole

Base Information

• Chemical Name: 5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole
• CAS No.: 289725-98-0
• Molecular Formula: C₄₂H₄₄N₂O₃Si
• Molecular Weight: 652.908
• Mol file: 289725-98-0.mol

Synonyms:5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole

Chemical Property of 5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole

There total 7 articles about 5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole → 5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole (289725-98-0)

Guidance literature:

With Mn₂O; In benzene; at 20 ℃; for 25h;

DOI:10.1021/ol0062650

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole (289725-98-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 15 percent / sodium hydroxide / ethanol; H₂O / 72 h / 75 °C

2.1: 64 percent / imidazole / dimethylformamide / 16 h / 20 °C

3.1: 74 percent / dimethylformamide / 20 h / 85 °C

4.1: lithium diisopropylamide / tetrahydrofuran; petroleum ether / 1 h / -78 °C

4.2: 36 percent / tetrahydrofuran; petroleum ether / -78 - 20 °C

5.1: 63 percent / Mn₂O / benzene / 25 h / 20 °C

With 1H-imidazole; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; Petroleum ether; benzene; 1.1: Addition / 2.1: Etherification / 3.1: Condensation / 4.1: Metallation / 4.2: Alkylation / 5.1: Oxidation;

DOI:10.1021/ol0062650

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole (289725-98-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 64 percent / imidazole / dimethylformamide / 16 h / 20 °C

2.1: 74 percent / dimethylformamide / 20 h / 85 °C

3.1: lithium diisopropylamide / tetrahydrofuran; petroleum ether / 1 h / -78 °C

3.2: 36 percent / tetrahydrofuran; petroleum ether / -78 - 20 °C

4.1: 63 percent / Mn₂O / benzene / 25 h / 20 °C

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; Petroleum ether; benzene; 1.1: Etherification / 2.1: Condensation / 3.1: Metallation / 3.2: Alkylation / 4.1: Oxidation;

DOI:10.1021/ol0062650

upstream raw materials:

4-hydroxy-benzaldehyde

tert-butylchlorodiphenylsilane

1-(4-methoxyphenyl)ethanone

(2E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one

Downstream raw materials:

4-[2,5-bis-(4-methoxyphenyl)-4-propyl-2H-pyrazol-3-yl]-phenol