2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-, (2E)-

Base Information

• Chemical Name: 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-, (2E)-
• CAS No.: 160210-32-2
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Mol file: 160210-32-2.mol

Synonyms:3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)propenone;4-hydroxy-4-methoxychalcone;4'-methoxy-4-hydroxychalcone;(E)-4-hydroxy-4'-methoxychalcone;3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one;(E)-3-(4-Hydroxy-phenyl)-1-(4-methoxy-phenyl)-propenone;3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-prop-2-en-1-one;

Chemical Property of 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-, (2E)-

Chemical Property:

• PSA: 46.53000
• LogP: 3.29690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-, (2E)-

There total 19 articles about 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-(4-bromophenyl)-1-(4-methoxyphenyl)-(2E)-2-propen-1-one (126443-18-3) → (2E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (160210-32-2)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); p-methylbenzaldehyde oxime; caesium carbonate; tert-butyl XPhos; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c9nj05124d

Reference yield: 96.0%

(E)-1-(4-Methoxy-phenyl)-3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone → (2E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (160210-32-2)

Guidance literature:

With β‐cyclodextrin; In water; at 60 ℃; for 0.133333h; Microwave irradiation;

DOI:10.1039/c5ra15996b

Reference yield: 96.0%

(E)-3-(4-(methoxymethoxy)phenyl)-1-(4-methoxyphenyl)prop-2-en-1-one → (2E)-3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (160210-32-2)

Guidance literature:

With ytterbium(III) chloride; In neat (no solvent); at 70 - 120 ℃; for 0.0416667h; Microwave irradiation; Green chemistry;

DOI:10.1002/jhet.2517

upstream raw materials:

4-hydroxy-benzaldehyde

1-(4-methoxyphenyl)ethanone

(E)-1,3-bis(4-methoxyphenyl)-2-propene-1-one

4-(tetrahydropyran-2-yloxy)benzaldehyde

Downstream raw materials:

5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-1,3-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-methyl-1,3-bis(4-methoxyphenyl)-1H-pyrazole

5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-ethyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole

5-[4-(tert-butyldiphenylsilanyloxy)phenyl]-4-propyl-1,3-bis(4-methoxyphenyl) 1H-pyrazole