methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

Base Information

Chemical Name:methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate
CAS No.:934470-35-6
Molecular Formula:C₁₈H₁₃N₃O₂
Molecular Weight:303.32
Hs Code.:

Synonyms:methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

Suppliers and Price of methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

There total 8 articles about methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934470-34-5
methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

: 934470-35-6
methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 15h;

Reference yield:

: 835898-37-8
1-(benzyloxy)-4-bromo-2-cyanobenzene

: 934470-35-6
methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane; toluene / -78 - 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 100 °C

3: trifluoroacetic acid / pentamethylbenzene, / Heating / reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 130 °C / Microwave irradiation

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 20 °C

With n-butyllithium; Triisopropyl borate; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; pentamethylbenzene,; water; toluene;

Reference yield:

: (3-cyano-4-benzyloxyphenyl)boronic acid

: 934470-35-6
methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 100 °C

2: trifluoroacetic acid / pentamethylbenzene, / Heating / reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 130 °C / Microwave irradiation

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 20 °C

With tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; pentamethylbenzene,; water; toluene;