(R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate
CAS No.:1225327-17-2
Molecular Formula:C₂₉H₂₈N₂O₅S
Molecular Weight:516.618
Hs Code.:

Synonyms:(R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

There total 5 articles about (R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1225327-16-1
5-(2-(phenylsulfonyl)ethyl)-1H-indole

: 61350-62-7
N-benzyloxycarbonyl-D-proline acid chloride

: 1225327-17-2
(R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: 5-(2-(phenylsulfonyl)ethyl)-1H-indole; With ethylmagnesium bromide; In diethyl ether; dichloromethane; for 0.5h; Reflux;

N-benzyloxycarbonyl-D-proline acid chloride; zinc(II) chloride; In diethyl ether; dichloromethane; at -25 - -15 ℃; for 10h;

Reference yield:

: (E)-5-(2-(phenylsulfonyl)vinyl)-1H-indole

: 1225327-17-2
(R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2327.23 - 2585.81 Torr

2.1: ethylmagnesium bromide / dichloromethane; diethyl ether / 0.5 h / Reflux

2.2: 10 h / -25 - -15 °C

With ethylmagnesium bromide; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1225327-17-2
(R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 95 - 105 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2327.23 - 2585.81 Torr

3.1: ethylmagnesium bromide / dichloromethane; diethyl ether / 0.5 h / Reflux

3.2: 10 h / -25 - -15 °C

With ethylmagnesium bromide; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;