Technology Process of (R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate
There total 5 articles about (R)-benzyl 2-(5-(2-(phenylsulfonyl)ethyl)-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(2-(phenylsulfonyl)ethyl)-1H-indole;
With
ethylmagnesium bromide;
In
diethyl ether; dichloromethane;
for 0.5h;
Reflux;
N-benzyloxycarbonyl-D-proline acid chloride;
zinc(II) chloride;
In
diethyl ether; dichloromethane;
at -25 - -15 ℃;
for 10h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2327.23 - 2585.81 Torr
2.1: ethylmagnesium bromide / dichloromethane; diethyl ether / 0.5 h / Reflux
2.2: 10 h / -25 - -15 °C
With
ethylmagnesium bromide; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 95 - 105 °C
2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2327.23 - 2585.81 Torr
3.1: ethylmagnesium bromide / dichloromethane; diethyl ether / 0.5 h / Reflux
3.2: 10 h / -25 - -15 °C
With
ethylmagnesium bromide; hydrogen; triethylamine; tris-(o-tolyl)phosphine;
palladium 10% on activated carbon; palladium diacetate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;