N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline

Base Information

Chemical Name:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline
CAS No.:1352609-13-2
Molecular Formula:C₂₃H₂₁N₇O
Molecular Weight:411.466
Hs Code.:

Synonyms:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline

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Chemical Property of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline

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Technology Process of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline

There total 5 articles about N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₉N₇O

: 1352609-13-2
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 356560-84-4
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

: 1352609-13-2
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / tert-butyl methyl ether; methanol; water / 4 h / 20 °C

2.1: hydrogenchloride / water / 4 h / 70 °C

3.1: acetic acid / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C

4.2: 0 °C / pH 7-8

With hydrogenchloride; sodium tetrahydroborate; ammonium acetate; acetic acid; In tetrahydrofuran; methanol; tert-butyl methyl ether; water; 1,2-dichloro-ethane;
DOI:10.1021/jm500115w

Reference yield:

: 1352609-89-2
6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

: 1352609-13-2
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 4 h / 70 °C

2.1: acetic acid / 1,2-dichloro-ethane / 2 h / Reflux; Inert atmosphere

3.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 - 20 °C

3.2: 0 °C / pH 7-8

With hydrogenchloride; sodium tetrahydroborate; acetic acid; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm500115w