CPD3325-A8

Base Information

• Chemical Name: CPD3325-A8
• CAS No.: 1352609-91-6
• Molecular Formula: C₁₆H₁₂N₆O
• Molecular Weight: 304.311
• Mol file: 1352609-91-6.mol

Synonyms:4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde

Chemical Property of CPD3325-A8

Chemical Property:

• PKA: 6.37±0.10(Predicted)
• Density: 1.47±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methyl-pyridin-2-yl)-1H-imidazole-2-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CPD3325-A8

There total 5 articles about CPD3325-A8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine (1352609-89-2) → 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde (1352609-91-6)

Guidance literature:

With hydrogenchloride; In water; at 70 ℃; for 4h;

DOI:10.1016/j.bmc.2014.03.022

Reference yield:

1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (356560-84-4) → 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde (1352609-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate / water; tert-butyl methyl ether; methanol / 3 h / 20 °C

1.2: pH 8

2.1: hydrogenchloride; water / 3 h / 70 °C

2.2: 0 °C

With hydrogenchloride; ammonium acetate; water; In methanol; tert-butyl methyl ether; water;

Reference yield:

1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone (614750-82-2) → 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde (1352609-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C

2.1: ammonium acetate / water; tert-butyl methyl ether; methanol / 3 h / 20 °C

2.2: pH 8

3.1: hydrogenchloride; water / 3 h / 70 °C

3.2: 0 °C

With hydrogenchloride; ammonium acetate; water; hydrogen bromide; dimethyl sulfoxide; In methanol; tert-butyl methyl ether; water;

upstream raw materials:

1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone

1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

6-methyl-2-pyridinecarboxaldehyde

Downstream raw materials:

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline sulfate

3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)-4-((dimethylamino)methyl)benzonitrile

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-methoxyaniline