2-BOC-6-METHOXY-3,4-DIHYDRO-1H-ISOQUINOLINE-1-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-BOC-6-METHOXY-3,4-DIHYDRO-1H-ISOQUINOLINE-1-CARBOXYLIC ACID
• CAS No.: 499139-27-4
• Molecular Formula: C16H21 N O5
• Molecular Weight: 307.346
• Mol file: 499139-27-4.mol

Synonyms:2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-6-methoxyisoquinoline-1-carboxylicacid

Chemical Property of 2-BOC-6-METHOXY-3,4-DIHYDRO-1H-ISOQUINOLINE-1-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 7.59E-10mmHg at 25°C
• Boiling Point: 475.4°C at 760 mmHg
• PKA: 3.65±0.20(Predicted)
• Flash Point: 241.3°C
• PSA: 76.07000
• Density: 1.225g/cm³
• LogP: 2.55200

Purity/Quality:

97% ^*data from raw suppliers

2-Boc-6-methoxy-3,4-dihydro-1H-isoquinoline-1-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-BOC-6-METHOXY-3,4-DIHYDRO-1H-ISOQUINOLINE-1-CARBOXYLIC ACID

There total 15 articles about 2-BOC-6-METHOXY-3,4-DIHYDRO-1H-ISOQUINOLINE-1-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-ethyl 2-tert-butyl 6-methoxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate → 2-(tert-butoxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (499139-27-4,2703745-74-6,2703746-30-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 2h;

Reference yield:

C17H23NO5 (531556-16-8) → 2-(tert-butoxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (499139-27-4,2703745-74-6,2703746-30-7)

Guidance literature:

With methanol; lithium hydroxide monohydrate; In tetrahydrofuran; for 12h;

Reference yield:

ethyl (1SR)-6-hydroxy-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate (128073-49-4) → 2-(tert-butoxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (499139-27-4,2703745-74-6,2703746-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

2: lithium hydroxide / tetrahydrofuran; water; ethanol / 2 h / 20 °C

With caesium carbonate; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

C₁₇H₂₃NO₅

methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate

di-tert-butyl dicarbonate

ethyl (1SR)-6-hydroxy-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate

Downstream raw materials:

(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

4-(6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoracetate

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