2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

Base Information

• Chemical Name: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate
• CAS No.: 350014-19-6
• Molecular Formula: C16H21NO5
• Molecular Weight: 307.346
• Mol file: 350014-19-6.mol

Synonyms:2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate;2-tert-butyl 1-methyl 3,4-dihydro-6-hydroxyisoquinoline-1,2(1H)-dicarboxylate

Chemical Property of 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

Chemical Property:

• PSA: 76.07000
• LogP: 2.33740

Purity/Quality:

2-tert-Butyl1-methyl6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

There total 9 articles about 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester (350014-18-5) → methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate (350014-19-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) → methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate (350014-19-6)

Guidance literature:

With triethylamine; In tetrahydrofuran;

Reference yield: 46.0%

dimethyl sulfate (77-78-1) + 2-(tert-butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (362492-00-0) → methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate (350014-19-6)

Guidance literature:

2-(tert-butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.666667h;

dimethyl sulfate; In tetrahydrofuran; for 3h; Heating / reflux;

upstream raw materials:

di-tert-butyl dicarbonate

1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester

dimethyl sulfate

2-(tert-butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Downstream raw materials:

C₂₈H₃₉N₃O₃

1-[[[(R)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester

1-[[[(S)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester

C₃₅H₃₇N₃O₃