Technology Process of 3,5-O-benzylidene-1-O-[tert-butyl(dimethyl)silyl]-2,4,7,8-tetradeoxy-2,4,8-trimethyl-6-C-methyl-6-O-(triethylsilyl)-L-threo-L-ido-nonitol
There total 9 articles about 3,5-O-benzylidene-1-O-[tert-butyl(dimethyl)silyl]-2,4,7,8-tetradeoxy-2,4,8-trimethyl-6-C-methyl-6-O-(triethylsilyl)-L-threo-L-ido-nonitol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphate buffer; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 0 ℃;
for 2h;
pH=7;
DOI:10.1002/anie.200500172
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.20 g / EtMgBr / CH2Cl2; diethyl ether; propan-2-ol / 0 - 20 °C
2: 82 percent / TPAP; NMO; 4 Angstroem molecular sieves / CH2Cl2 / 2 h / 20 °C
3: 64 percent / t-BuLi; MgBr2 / diethyl ether; pentane; various solvents / 1 h / -78 °C
4: 93 percent / 2,6-lutidine / CH2Cl2 / 1 h / 0 °C
5: 89 percent / Raney-Ni; boric acid; H2 / methanol; H2O / 2 h / 20 °C
6: 60 percent / Zn(BH4)2 / diethyl ether; CH2Cl2 / -78 - -30 °C
7: 87 percent / CSA / toluene / 1.5 h / 20 °C / 7.5 Torr
8: 85 percent / DDQ; aq. phosphate buffer / CH2Cl2 / 2 h / 0 °C / pH 7
With
2,6-dimethylpyridine; N-methyl-2-indolinone; phosphate buffer; tetrapropylammonium perruthennate; zinc(II) tetrahydroborate; 4 A molecular sieve; camphor-10-sulfonic acid; ethylmagnesium bromide; hydrogen; tert.-butyl lithium; boric acid; nickel; 2,3-dicyano-5,6-dichloro-p-benzoquinone; magnesium bromide;
In
methanol; diethyl ether; dichloromethane; various solvents; water; isopropyl alcohol; toluene; pentane;
DOI:10.1002/anie.200500172
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 64 percent / t-BuLi; MgBr2 / diethyl ether; pentane; various solvents / 1 h / -78 °C
2: 93 percent / 2,6-lutidine / CH2Cl2 / 1 h / 0 °C
3: 89 percent / Raney-Ni; boric acid; H2 / methanol; H2O / 2 h / 20 °C
4: 60 percent / Zn(BH4)2 / diethyl ether; CH2Cl2 / -78 - -30 °C
5: 87 percent / CSA / toluene / 1.5 h / 20 °C / 7.5 Torr
6: 85 percent / DDQ; aq. phosphate buffer / CH2Cl2 / 2 h / 0 °C / pH 7
With
2,6-dimethylpyridine; phosphate buffer; zinc(II) tetrahydroborate; camphor-10-sulfonic acid; hydrogen; tert.-butyl lithium; boric acid; nickel; 2,3-dicyano-5,6-dichloro-p-benzoquinone; magnesium bromide;
In
methanol; diethyl ether; dichloromethane; various solvents; water; toluene; pentane;
DOI:10.1002/anie.200500172
![3,5-O-benzylidene-1-O-[tert-butyl(dimethyl)silyl]-2,4,7,8-tetradeoxy-9-O-(4-methoxybenzyl)-2,4,8-trimethyl-6-C-methyl-6-O-(triethylsilyl)-L-threo-L-ido-nonitol](/Databaselist/images/loading.webp)
