tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1261071-89-9
Molecular Formula:C₃₂H₃₈BN₅O₄
Molecular Weight:567.496
Hs Code.:

Synonyms:tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 16 articles about tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1261071-88-8
C₂₆H₂₆BrN₅O₂

: 73183-34-3
bis(pinacol)diborane

: 1261071-89-9
C₃₂H₃₈BN₅O₄

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; Reflux;
DOI:10.1002/cmdc.201400045

Reference yield:

: 1261071-88-8
tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

: 73183-34-3
bis(pinacol)diborane

: 1261071-89-9
tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; for 1.5h; Inert atmosphere; Reflux;

Reference yield:

: 55687-02-0
6-bromo-2-chloro-quinoxaline

: 1261071-89-9
tert-butyl (2S)-2-(5-{4-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 30 °C / Inert atmosphere

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

With potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane;