1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one

Base Information

Chemical Name:1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one
CAS No.:1314012-48-0
Molecular Formula:C₁₈H₁₃F₂NO₃
Molecular Weight:329.303
Hs Code.:

Synonyms:1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one

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Chemical Property of 1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one

Chemical Property:

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Technology Process of 1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one

There total 3 articles about 1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314012-47-9
[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-trimethylsilyloxy-acetonitrile

: 75-16-1
methylmagnesium bromide

: 1314012-48-0
1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one

Guidance literature:: [2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-trimethylsilyloxy-acetonitrile; methylmagnesium bromide; In diethyl ether; at 20 ℃; for 4h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

: 437-81-0
2,6-difluorobenzaldehyde

: 1314012-48-0
1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 3 h / Reflux

2.1: titanium(IV) isopropylate / dichloromethane / 0 - 20 °C

2.2: 2 h / 20 °C

3.1: diethyl ether / 4 h / 20 °C / Reflux

3.2: 4 h / 20 °C

With titanium(IV) isopropylate; potassium carbonate; In diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 1261784-49-9
8-fluoro-3-hydroxyquinoline

: 1314012-48-0
1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-1-hydroxy-propan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 3 h / Reflux

2.1: titanium(IV) isopropylate / dichloromethane / 0 - 20 °C

2.2: 2 h / 20 °C

3.1: diethyl ether / 4 h / 20 °C / Reflux

3.2: 4 h / 20 °C

With titanium(IV) isopropylate; potassium carbonate; In diethyl ether; dichloromethane; acetonitrile;