(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

Base Information

Chemical Name:(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride
CAS No.:1429397-50-1
Molecular Formula:C₁₄H₁₃Cl₂NO*ClH
Molecular Weight:318.63
Hs Code.:

Synonyms:(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

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Chemical Property of (1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

Chemical Property:

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Technology Process of (1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

There total 7 articles about (1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1429387-27-8
tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

: 1429397-50-1
(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm401767k

Reference yield:

: 29559-24-8
4-chlorophenylnitromethane

: 587-04-2
m-Chlorobenzaldehyde

: 1429397-50-1
(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

: (1S,2S)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

Guidance literature:: 4-chlorophenylnitromethane; m-Chlorobenzaldehyde; With pyridine; aluminum oxide; triethylsilyl chloride; at 20 ℃; for 16h; Darkness;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 43189-37-3,7292-70-8
(R)-2-amino-2-(4-chlorophenyl)acetic acid

: 1429397-50-1
(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

1.2: Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane; water / 2 h / 25 °C / Inert atmosphere

4.1: magnesium; iodine / diethyl ether / 0.5 h / Inert atmosphere; Reflux

4.2: 25 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; iodine; Dess-Martin periodane; magnesium; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water;
DOI:10.1021/jm401767k