tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

Base Information

Chemical Name:tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate
CAS No.:1429387-27-8
Molecular Formula:C₁₉H₂₁Cl₂NO₃
Molecular Weight:382.287
Hs Code.:

Synonyms:tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

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Chemical Property of tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

Chemical Property:

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Technology Process of tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

There total 4 articles about tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067658-27-8
(R)-2-amino-2-(4-chlorophenyl)ethanol

: 1429387-27-8
tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane; water / 2 h / 25 °C / Inert atmosphere

3.1: magnesium; iodine / diethyl ether / 0.5 h / Inert atmosphere; Reflux

3.2: 25 °C / Inert atmosphere

With iodine; Dess-Martin periodane; magnesium; triethylamine; In diethyl ether; dichloromethane; water;
DOI:10.1021/jm401767k

Reference yield:

: 43189-37-3,7292-70-8
(R)-2-amino-2-(4-chlorophenyl)acetic acid

: 1429387-27-8
tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

1.2: Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane; water / 2 h / 25 °C / Inert atmosphere

4.1: magnesium; iodine / diethyl ether / 0.5 h / Inert atmosphere; Reflux

4.2: 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; iodine; Dess-Martin periodane; magnesium; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jm401767k

Reference yield:

: 1429382-71-7
(R)-tert-butyl (1-(4-chlorophenyl)-2-hydroxyethyl)carbamate

: 1429387-27-8
tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane; water / 2 h / 25 °C / Inert atmosphere

2.1: magnesium; iodine / diethyl ether / 0.5 h / Inert atmosphere; Reflux

2.2: 25 °C / Inert atmosphere

With iodine; Dess-Martin periodane; magnesium; In diethyl ether; dichloromethane; water;
DOI:10.1021/jm401767k