cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

Base Information

Chemical Name:cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide
CAS No.:89848-13-5
Molecular Formula:C₃₀H₃₂Cl₂N₈O₄
Molecular Weight:639.541
Hs Code.:

Synonyms:cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

There total 8 articles about cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 89848-11-3
cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

: 89848-13-5
cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

Guidance literature:: With hydrazine hydrate; In 1,4-dioxane; for 3h; Heating;
DOI:10.1021/jm00373a015

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 89848-13-5
cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

2: 80 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

3: 86 percent / pyridine / CHCl₃ / 3 h

4: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating

With thiophene; pyridine; hydrogen; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00373a015

Reference yield:

: 67914-86-7,854372-78-4
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-13-5
cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) Me₂SO, 1 h, 2.) Me₂SO, 80 deg C, 5 h

2: 70 percent / NaOH / butan-1-ol / Heating

3: 50 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

4: 80 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

5: 86 percent / pyridine / CHCl₃ / 3 h

6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating

With thiophene; pyridine; sodium hydroxide; hydrogen; sodium hydride; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015