methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate

Base Information

Chemical Name:methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate
CAS No.:957941-15-0
Molecular Formula:C₂₃H₂₄F₃N₃O₅
Molecular Weight:479.456
Hs Code.:

Synonyms:methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate

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Chemical Property of methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate

Chemical Property:

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Technology Process of methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate

There total 7 articles about methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957941-07-0
4-{4-[2-(trifluromethyl)phenoxy]piperidin-1-yl}benzohydrazide

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 957941-15-0
methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate

Guidance literature:: In dichloromethane; water; at 0 - 20 ℃; for 0.25h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 957941-15-0
methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos / 1,2-dimethoxyethane / Heating / reflux

4: hydrazine / methanol / 85 °C

5: dichloromethane; water / 0.25 h / 0 - 20 °C

With potassium phosphate; triphenylphosphine; trifluoroacetic acid; hydrazine; diethylazodicarboxylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 824390-04-7
4-(2-(trifluoromethyl)phenoxy)piperidine

: 957941-15-0
methyl 3-oxo-3-[2-(4-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}benzoyl)hydrazino]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos / 1,2-dimethoxyethane / Heating / reflux

2: hydrazine / methanol / 85 °C

3: dichloromethane; water / 0.25 h / 0 - 20 °C

With potassium phosphate; hydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In methanol; 1,2-dimethoxyethane; dichloromethane; water;