(E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate

Base Information

Chemical Name:(E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate
CAS No.:1369894-40-5
Molecular Formula:C₁₈H₂₅NO₆S
Molecular Weight:383.466
Hs Code.:

Synonyms:(E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate

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Chemical Property of (E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate

Chemical Property:

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Technology Process of (E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate

There total 1 articles about (E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37746-78-4
4-bromo-trans-crotonic acid ethyl ester

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 1369894-40-5
(E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.01.021

Reference yield:

: 1369894-40-5
(E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate

: (E)-ethyl 4-(4-methylphenylsulfonamido)but-2-enoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.tetasy.2012.01.021

Reference yield:

: 1369894-40-5
(E)-ethyl 4-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)but-2-enoate

: 1369894-11-0
ethyl 2-(5-cyclohexyl-4-nitro-1-tosylpyrrolidin-3-yl)-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((2S,4S,8R)-8-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)thiourea / toluene / 22 h / 20 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((2S,4S,8R)-8-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)thiourea; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1016/j.tetasy.2012.01.021