2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester

Base Information

Chemical Name:2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester
CAS No.:219657-66-6
Molecular Formula:C₃₀H₃₁N₃O₅
Molecular Weight:513.593
Hs Code.:

Synonyms:2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester

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Chemical Property of 2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester

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Technology Process of 2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester

There total 5 articles about 2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 74-89-5
methylamine

: 2-(1-(methoxycarbonyl)-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl ester

: 219657-66-6
2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester

Guidance literature:: With TEA; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; water; for 16h;
DOI:10.1021/jm980414r

Reference yield:

: 615-43-0
2-iodophenylamine

: 219657-66-6
2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Rh₂(OAc)4 / toluene / 0.5 h

2: 34 percent / K₂CO₃, Pd(Cl)2(PPh₃)2 / dioxane; H₂O / 16 h / 125 °C / 10343 Torr

3: 67 percent / EDC, TEA, HOBt / CH₂Cl₂; H₂O / 16 h

With bis-triphenylphosphine-palladium(II) chloride; dirhodium tetraacetate; TEA; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1021/jm980414r

Reference yield:

: 196811-04-8
(S)-amino-3-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>propionic acid methyl ester

: 219657-66-6
2-(1-carboxy-2-<4-<2-(5-methyl-2-phenyloxazol-4-yl)ethoxy>phenyl>ethylamino)benzoic acid methyl amide methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / isoamyl nitrite, acetic acid / CHCl₃ / 3 h / Heating

2: 86 percent / Rh₂(OAc)4 / toluene / 0.5 h

3: 34 percent / K₂CO₃, Pd(Cl)2(PPh₃)2 / dioxane; H₂O / 16 h / 125 °C / 10343 Torr

4: 67 percent / EDC, TEA, HOBt / CH₂Cl₂; H₂O / 16 h

With bis-triphenylphosphine-palladium(II) chloride; dirhodium tetraacetate; TEA; potassium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; isopentyl nitrite; In 1,4-dioxane; dichloromethane; chloroform; water; toluene;
DOI:10.1021/jm980414r