methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

Base Information

Chemical Name:methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate
CAS No.:133486-29-0
Molecular Formula:C₂₆H₃₀ClN₃O₄
Molecular Weight:483.995
Hs Code.:

Synonyms:methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

Suppliers and Price of methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

There total 7 articles about methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133486-28-9
methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

: 133486-29-0
methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

Guidance literature:: With dmap; acetic anhydride; In dichloromethane; water;

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 133486-29-0
methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

6: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

With dmap; manganese(IV) oxide; sodium hydroxide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jm00099a013

Reference yield:

: 133486-42-7
2-n-butyl-5-(acetoxymethyl)-1-<(2-chlorophenyl)methyl>imidazole

: 133486-29-0
methyl-3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-[(pyridin-4-yl)methyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 10percent aq. NaOH / methanol / 4 h / Heating

2: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

4: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

With dmap; manganese(IV) oxide; sodium hydroxide; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jm00099a013