methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

Base Information

Chemical Name:methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate
CAS No.:133486-28-9
Molecular Formula:C₂₄H₂₈ClN₃O₃
Molecular Weight:441.958
Hs Code.:

Synonyms:methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

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Chemical Property of methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

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Technology Process of methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

There total 8 articles about methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90610-07-4
4-pyridinepropanoic acid methyl ester

: 4-pyridine

: 133485-56-0
2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazole-5-carboxaldehyde

: 133486-28-9
methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

Guidance literature:: With n-butyllithium; hydrogen; diisopropylamine; palladium; In tetrahydrofuran; 1,2-dimethoxyethane; ethyl acetate; toluene;

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 90610-07-4
4-pyridinepropanoic acid methyl ester

: 5927-18-4
trimethyl phosphonoacetate

: 133485-56-0
2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazole-5-carboxaldehyde

: 133486-28-9
methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

Guidance literature:: With n-butyllithium; hydrogen; diisopropylamine; palladium; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate; toluene;

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 133486-28-9
methyl-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-3-hydroxy-2-[(pyridin-4-yl)methyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

With manganese(IV) oxide; sodium hydroxide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jm00099a013