3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

Base Information

Chemical Name:3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester
CAS No.:1254831-48-5
Molecular Formula:C₂₄H₃₄N₄O₄
Molecular Weight:442.558
Hs Code.:

Synonyms:3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

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Chemical Property of 3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

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Technology Process of 3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

There total 2 articles about 3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1254831-46-3
(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

: 304873-96-9
(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

: 1254831-48-5
3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

Guidance literature:: (E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.333333h;

(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; for 1h;

With potassium carbonate; In tetrahydrofuran; water; ethyl acetate; pH=10.5;

Reference yield:

: 1254831-47-4
(1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester

: 1254831-48-5
3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / ethanol / 1 h / 25 - 35 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C

2.2: 1 h

With sodium ethanolate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;

Reference yield: 99.0%

: 1254831-48-5
3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

: 3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

Guidance literature:: 3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester; With hydrogenchloride; In ethanol; at 20 ℃; for 2h; Reflux;

With potassium carbonate; In water; pH=9;