(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

Base Information

Chemical Name:(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt
CAS No.:1438404-18-2
Molecular Formula:C₁₇H₂₁N₄O₂*Na
Molecular Weight:336.369
Hs Code.:

Synonyms:(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

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Chemical Property of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

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Technology Process of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

There total 6 articles about (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375150-73-4
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid

: 1438404-18-2
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

Guidance literature:: With sodium hydroxide; In ethanol; water; at 0 - 55 ℃; Temperature; Time;

Reference yield:

: 1254831-46-3
(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

: 1438404-18-2
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C

1.2: 1 h

2.1: hydrogenchloride / ethanol / 2 h / 25 °C / Reflux

3.1: trifluoroacetic acid / ethanol / Resolution of racemate

4.1: water; acetone / 10 °C / Inert atmosphere

4.2: 3 h / 20 - 22 °C

5.1: hydrogenchloride / water

6.1: sodium hydroxide / water; acetone / 1 - 55 °C

With hydrogenchloride; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; acetone;

Reference yield:

: 1254831-47-4
(1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester

: 1438404-18-2
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium ethanolate / ethanol / 1 h / 25 - 35 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C

2.2: 1 h

3.1: hydrogenchloride / ethanol / 2 h / 25 °C / Reflux

4.1: trifluoroacetic acid / ethanol / Resolution of racemate

5.1: water; acetone / 10 °C / Inert atmosphere

5.2: 3 h / 20 - 22 °C

6.1: hydrogenchloride / water

7.1: sodium hydroxide / water; acetone / 1 - 55 °C

With hydrogenchloride; sodium ethanolate; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; acetone;