(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

Base Information

Chemical Name:(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester
CAS No.:1254831-46-3
Molecular Formula:C₁₇H₂₄N₂O₅
Molecular Weight:336.388
Hs Code.:

Synonyms:(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

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Chemical Property of (E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

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Technology Process of (E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

There total 1 articles about (E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1254831-47-4
(1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester

: 95-92-1
oxalic acid diethyl ester

: 1254831-46-3
(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

Guidance literature:: (1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester; oxalic acid diethyl ester; With sodium ethanolate; In ethanol; at 25 - 35 ℃; for 1h;

pH=6.2; Aqueous phosphate buffer;

Reference yield: 47.0%

: 1254831-46-3
(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

: 304873-96-9
(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

: 1254831-48-5
3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

Guidance literature:: (E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.333333h;

(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; for 1h;

With potassium carbonate; In tetrahydrofuran; water; ethyl acetate; pH=10.5;

Reference yield:

: 1254831-46-3
(E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester

: 1438404-18-2
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C

1.2: 1 h

2.1: hydrogenchloride / ethanol / 2 h / 25 °C / Reflux

3.1: trifluoroacetic acid / ethanol / Resolution of racemate

4.1: water; acetone / 10 °C / Inert atmosphere

4.2: 3 h / 20 - 22 °C

5.1: hydrogenchloride / water

6.1: sodium hydroxide / water; acetone / 1 - 55 °C

With hydrogenchloride; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; acetone;