3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en

Base Information

Chemical Name:3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en
CAS No.:87080-71-5
Molecular Formula:C₃₆H₅₂ClN₃O₃Si
Molecular Weight:638.366
Hs Code.:

Synonyms:3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en

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Chemical Property of 3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en

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Technology Process of 3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en

There total 9 articles about 3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 87080-70-4
22-Chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en-3β-ol

: 87080-71-5
3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1002/jlac.198319830615

Reference yield:

: 4233-33-4
4-Phenyl-1,2,4-triazolidine-3,5-dione

: 87080-71-5
3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en

Guidance literature:: Multi-step reaction with 3 steps

1: 1) trimethylphosphite / 1) 90 min, 125 deg C, xylol; 2) CH₂Cl₂

2: 95 percent / Na / methanol / 2 h / Heating

3: 90 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

With 1H-imidazole; sodium; phosphorous acid trimethyl ester; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198319830615

Reference yield:

: 40736-33-2
(20S)-20-hydroxymethylpregn-4-en-3-one

: 87080-71-5
3β-(tert-Butyldimethylsilyloxy)-22-chlor-5α,8α-(4-phenyl-1,2-urazolo)-23,24-dinorchol-6-en

Guidance literature:: Multi-step reaction with 8 steps

1: 51 percent / triphenylphosphane, CCl₄ / 48 h / Heating

2: 88 percent / p-toluenesulfonic acid / 1 h / 80 - 90 °C

3: 90 percent / NaBH₄/H₂O / tetrahydrofuran; 2-methoxy-ethanol / 24 h / Ambient temperature

4: 88 percent / pyridine / 12 h / Ambient temperature

5: N-bromosuccinimide, dibenzoylperoxide / CCl₄ / 0.17 h / 80 °C / Irradiation

6: 1) trimethylphosphite / 1) 90 min, 125 deg C, xylol; 2) CH₂Cl₂

7: 95 percent / Na / methanol / 2 h / Heating

8: 90 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

With 1H-imidazole; tetrachloromethane; sodium tetrahydroborate; N-Bromosuccinimide; water; sodium; toluene-4-sulfonic acid; triphenylphosphine; phosphorous acid trimethyl ester; dibenzoyl peroxide; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198319830615