Technology Process of 2-(4-methoxyphenyl)-3-oxo-3-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile
There total 5 articles about 2-(4-methoxyphenyl)-3-oxo-3-(2,3-dimethoxy-4,5-methylenedioxyphenyl)propanenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
p-methoxybenzylnitrile;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.5h;
Inert atmosphere;
2,3-dimethoxy-4,5-methylenedioxybenzoic acid methyl ester;
In
tetrahydrofuran; mineral oil;
Reflux;
Inert atmosphere;
DOI:10.1021/np400310m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: urea hydrogen peroxide adduct / methanol / 1.5 h / Reflux
2.1: thionyl chloride / 1 h / Reflux
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.2: Reflux; Inert atmosphere
With
thionyl chloride; urea hydrogen peroxide adduct; sodium hydride;
In
tetrahydrofuran; methanol; mineral oil;
DOI:10.1021/np400310m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / 1 h / Reflux
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
2.2: Reflux; Inert atmosphere
With
thionyl chloride; sodium hydride;
In
tetrahydrofuran; mineral oil;
DOI:10.1021/np400310m
