Cis-(+/-)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine

Base Information

• Chemical Name: Cis-(+/-)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine
• CAS No.: 91797-58-9
• Molecular Formula: C16H15 Cl2 N
• Molecular Weight: 292.203
• Mol file: 91797-58-9.mol

Synonyms:1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, cis- (9CI); 1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, cis-(?à)-

Chemical Property of Cis-(+/-)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine

Chemical Property:

• Boiling Point: 409.6±45.0 °C(Predicted)
• PKA: 9.13±0.40(Predicted)
• PSA: 26.02000
• Density: 1.259±0.06 g/cm3(Predicted)
• LogP: 5.61920

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cis-(+/-)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine

There total 3 articles about Cis-(+/-)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one (79560-19-3,79836-44-5) → 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine + 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine (91797-58-9)

Guidance literature:

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one; With ammonium acetate; In isopropyl alcohol; at 80 - 85 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In isopropyl alcohol; at 85 ℃; for 16h; Overall yield = 56 percent; Inert atmosphere;

DOI:10.1016/j.bmcl.2021.127997

Reference yield:

α-naphthol (90-15-3) → 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine + 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine (91797-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 2.5 h / 100 °C / Inert atmosphere

2.1: ammonium acetate / isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere

2.2: 16 h / 85 °C / Inert atmosphere

With aluminum (III) chloride; ammonium acetate; In isopropyl alcohol;

DOI:10.1016/j.bmcl.2021.127997

Reference yield:

1,2-dichloro-benzene (95-50-1) → 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine + 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine (91797-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 2.5 h / 100 °C / Inert atmosphere

2.1: ammonium acetate / isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere

2.2: 16 h / 85 °C / Inert atmosphere

With aluminum (III) chloride; ammonium acetate; In isopropyl alcohol;

DOI:10.1016/j.bmcl.2021.127997

upstream raw materials:

α-naphthol

1,2-dichloro-benzene

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one

Refernces