C₂₂H₂₂ClFN₂O₃

Base Information

Chemical Name:C₂₂H₂₂ClFN₂O₃
CAS No.:1415022-85-3
Molecular Formula:C₂₂H₂₂ClFN₂O₃
Molecular Weight:416.88
Hs Code.:

C<sub>22</sub>H<sub>22</sub>ClFN<sub>2</sub>O<sub>3</sub>

Synonyms:C₂₂H₂₂ClFN₂O₃

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Chemical Property of C₂₂H₂₂ClFN₂O₃

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Technology Process of C₂₂H₂₂ClFN₂O₃

There total 4 articles about C₂₂H₂₂ClFN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.6%

: 1415022-89-7
methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

: 1415022-85-3
C₂₂H₂₂ClFN₂O₃

Guidance literature:: With sodium hydroxide; In methanol; for 6h; Reflux;
DOI:10.1016/j.bmc.2012.09.065

Reference yield:

: 136834-55-4
C₁₅H₁₃FO₂

: 1415022-85-3
C₂₂H₂₂ClFN₂O₃

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / cyclohexane / 3 h / Reflux

2: potassium carbonate / acetonitrile / 6 h / 50 °C / Inert atmosphere; Reflux

3: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

4: sodium hydroxide / methanol / 6 h / Reflux

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; sodium hydroxide; In methanol; cyclohexane; acetonitrile;
DOI:10.1016/j.bmc.2012.09.065

Reference yield:

: 394-28-5
2-Bromo-5-fluorobenzoic acid

: 1415022-85-3
C₂₂H₂₂ClFN₂O₃

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 4 h / Reflux

2: palladium diacetate; potassium carbonate; triphenylphosphine / 5 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / cyclohexane / 3 h / Reflux

4: potassium carbonate / acetonitrile / 6 h / 50 °C / Inert atmosphere; Reflux

5: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

6: sodium hydroxide / methanol / 6 h / Reflux

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In methanol; cyclohexane; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.09.065