2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde

Base Information

• Chemical Name: 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde
• CAS No.: 219298-66-5
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.295
• Mol file: 219298-66-5.mol

Synonyms:2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde

Chemical Property of 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde

There total 5 articles about 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-6-methyl-4-(tetrahydropyran-2-yloxy)benzaldehyde (219298-65-4) + methyl iodide (74-88-4) → 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde (219298-66-5)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; for 1h; Ambient temperature;

DOI:10.1021/jm980410m

Reference yield:

orcinol (504-15-4) → 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde (219298-66-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) POCl₃, 3.) 2M aq. NaOH

2: pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

3: NaOH / dimethylsulfoxide / 1 h / Ambient temperature

With sodium hydroxide; pyridinium p-toluenesulfonate; trichlorophosphate; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm980410m

Reference yield:

2,4-dihydroxy-6-methylbenzaldehyde (487-69-4) → 2-methoxy-6-methyl-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde (219298-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

2: NaOH / dimethylsulfoxide / 1 h / Ambient temperature

With sodium hydroxide; pyridinium p-toluenesulfonate; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm980410m

upstream raw materials:

2-hydroxy-6-methyl-4-(tetrahydropyran-2-yloxy)benzaldehyde

methyl iodide

orcinol

2,4-dihydroxy-6-methylbenzaldehyde

Downstream raw materials:

Isoevernin aldehyde

2-methoxy-6-methyl-4-phenoxy-benzaldehyde

2-hydroxy-6-methyl-4-phenoxy-benzaldehyde

trifluoro-methanesulfonic acid 2-formyl-3-methyl-5-phenoxy-phenyl ester