2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one

Base Information

• Chemical Name: 2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one
• CAS No.: 1428486-00-3
• Molecular Formula: C₂₅H₁₉F₃N₄O₃
• Molecular Weight: 480.446
• Mol file: 1428486-00-3.mol

Synonyms:2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one

Chemical Property of 2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one

There total 3 articles about 2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

p-trifluoromethoxybenzaldehyde (659-28-9) + sodium 2-[4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}benzoylamino]acetate (1153619-02-3) → 2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one (1428486-00-3)

Guidance literature:

With sodium acetate; acetic anhydride; at 100 ℃;

DOI:10.1016/j.bmc.2013.01.014

Reference yield:

p-Aminohippuric acid (61-78-9) → 2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one (1428486-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / Reflux

1.2: Cooling with ice

2.1: acetic acid

3.1: sodium acetate; acetic anhydride / 100 °C

With sodium acetate; acetic anhydride; sodium carbonate; acetic acid;

DOI:10.1016/j.bmc.2013.01.014

Reference yield:

N-(p-aminobenzoyl)glycine diazonium salt (82588-16-7) → 2-(4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}phenyl)-4-{1-[4-(trifluoromethoxy)phenyl]methylidene}-1,3-oxazol-5-one (1428486-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: sodium acetate; acetic anhydride / 100 °C

With sodium acetate; acetic anhydride; acetic acid;

DOI:10.1016/j.bmc.2013.01.014

upstream raw materials:

p-trifluoromethoxybenzaldehyde

sodium 2-[4-{2-[4-(dimethylamino)phenyl]-1-diazenyl}benzoylamino]acetate

N-(p-aminobenzoyl)glycine diazonium salt

p-Aminohippuric acid