N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Base Information

Chemical Name:N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide
CAS No.:1357587-49-5
Molecular Formula:C₁₇H₁₃BrF₃N₃O₃S
Molecular Weight:476.274
Hs Code.:

Synonyms:N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

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Chemical Property of N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

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Technology Process of N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

There total 6 articles about N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1357587-48-4
2,5-difluoro-N-[2-fluoro-3-(2H-pyrazol-3-yl)-phenyl]-N-methoxymethylbenzenesulfonamide

: 1357587-49-5
N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1357587-49-5
N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

With pyridine; N-Bromosuccinimide; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1357587-49-5
N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

With pyridine; N-Bromosuccinimide; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; water;