N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide

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Chemical Name:N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide
CAS No.:1357588-03-4
Molecular Formula:C₂₄H₂₅BrF₃N₃O₅S
Molecular Weight:604.445
Hs Code.:

Synonyms:N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide

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Chemical Property of N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide

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Technology Process of N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide

There total 7 articles about N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 17739-45-6,59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 1357587-49-5
N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide

: 1357588-03-4
N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

2-(2-bromoethoxy)tetrahydropyran; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1357588-03-4
N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5.1: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 1 h / 0 °C

With pyridine; N-Bromosuccinimide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1357588-03-4
N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5.1: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 1 h / 0 °C

With pyridine; N-Bromosuccinimide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;