833451-52-8Relevant academic research and scientific papers
Efficient preparation of ((3-chloro-2-fluorophenyl)-[7-methoxy-8-(3- morpholin-4-yl-propoxy)-10,11-dihydro-5-oxa-2,4,11-triazadibenzo(a,d) cyclohepten-1-yl]-amine) for in-vivo study
Liu, Hu,Smith II, Leon M.,Mao, Yunyu,Pan, Weitao,Xu, Yong-Jiang,Burdzovic-Wizeman, Sabina,Duncton, Matthew A. J.,Wong, Wai C.
, p. 347 - 354 (2006)
An improved route for the preparation of highly functionalized 5,6-dihydropyrimido[4,5-b][1,4]oxazepine 1a in multigram quantities was developed. This new methodology was highlighted by the proper methoxy disposition via a regioselective methylation of 2,4,5-trihydroxy-benzaldehyde followed by a magnesium sulfate-promoted cyclization. Copyright Taylor & Francis LLC.
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase
Smith II, Leon,Wong, Wai C.,Kiselyov, Alexander S.,Burdzovic-Wizemann, Sabina,Mao, Yunyu,Xu, Yongjiang,Duncton, Matthew A.J.,Kim, Ki,Piatnitski, Evgueni L.,Doody, Jacqueline F.,Wang, Ying,Rosler, Robin L.,Milligan, Daniel,Columbus, John,Balagtas, Chris,Lee, Sui Ping,Konovalov, Andrey,Hadari, Yaron R.
, p. 5102 - 5106 (2007/10/03)
Novel tricyclic derivatives containing an oxazepine, thiazepine, or diazepine ring were studied for their EGFR tyrosine kinase inhibitory activity. While the oxazepines were in general more potent than thiazepines, the diazepines displayed somewhat differ
