Methyl piperidine-2-carboxylate hydrochloride

Base Information

• Chemical Name: Methyl piperidine-2-carboxylate hydrochloride
• CAS No.: 32559-18-5
• Molecular Formula: C7H13NO2.HCl
• Molecular Weight: 179.647
• Hs Code.: 2933399090
• European Community (EC) Number: 628-243-3
• DSSTox Substance ID: DTXSID10531754
• Mol file: 32559-18-5.mol

Synonyms:32559-18-5;methyl piperidine-2-carboxylate hydrochloride;Methyl pipecolinate hydrochloride;METHYL PIPECOLINATE, HCL;methyl piperidine-2-carboxylate;hydrochloride;2-piperidinecarboxylic acid methyl ester hydrochloride;MFCD00192316;methyl 2-piperidinecarboxylate hydrochloride;Methy pipecolinate HCl;Methyl pipecolinate HCl;2-Piperidinecarboxylic acid, methyl ester, hydrochloride;MFCD00237412;MFCD00672366;SCHEMBL1899822;DTXSID10531754;methyl pipecolinate hydro chloride;APCHKWZTSCBBJX-UHFFFAOYSA-N;AKOS005217011;Methyl pipecolinate hydrochloride, 97%;SB34643;SB42964;AS-11194;SY023681;SY030915;SY066252;METHYL PIPERIDINE-2-CARBOXYLATE HCL;Pipecolinic Acid Methyl Ester Hydrochloride;AM20090475;CS-0043132;M2591;EN300-23808;A821319;J-018783;piperidine-2-carboxylic acid methyl ester hydrochloride;F0001-0967;Methyl piperidine-2-carboxylate--hydrogen chloride (1/1)

Chemical Property of Methyl piperidine-2-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.0408mmHg at 25°C
• Melting Point: 205 °C (dec.)(lit.)
• Boiling Point: 235.3 °C at 760 mmHg
• Flash Point: 96.1 °C
• PSA: 38.33000
• LogP: 1.43230
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 179.0713064
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

98% ^*data from raw suppliers

Methyl pipecolinate hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CCCCN1.Cl
• Uses: Methyl Pipecolinate Hydrochloride is a reactant for synthesis of a pipecolic linker and antiviral agents.

Technology Process of Methyl piperidine-2-carboxylate hydrochloride

There total 6 articles about Methyl piperidine-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + pipecolic Acid (4043-87-2,83680-83-5) → methyl piperidine-2-carboxylate hydrochloride (32559-18-5)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; stereoselective reaction;

DOI:10.1002/ejoc.201402737

Reference yield: 91.0%

pipecolic Acid (4043-87-2,83680-83-5) → methyl piperidine-2-carboxylate hydrochloride (32559-18-5)

Guidance literature:

With thionyl chloride;

DOI:10.1016/S0040-4020(01)85023-7

Reference yield: 84.0%

1-oxy-pyridine-2-carboxylic acid methyl ester (38195-81-2) → methyl piperidine-2-carboxylate hydrochloride (32559-18-5)

Guidance literature:

1-oxy-pyridine-2-carboxylic acid methyl ester; With ammonium formate; 10percent palladium on carbon; In methanol; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1021/jo015649g

upstream raw materials:

methanol

pipecolic Acid

1-oxy-pyridine-2-carboxylic acid methyl ester

methyl (2RS)-6-oxopiperidine-2-carboxylate

Downstream raw materials:

4-Acetyl-2-(4-chloro-phenyl)-7,8,9,9a-tetrahydro-2H,6H-pyrido[1,2-d][1,2,4]triazin-1-one

4-Acetyl-2-p-tolyl-7,8,9,9a-tetrahydro-2H,6H-pyrido[1,2-d][1,2,4]triazin-1-one

methyl dl-N-acetylpipecolate

pipecolinic acid