2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

Base Information

Chemical Name:2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol
CAS No.:854045-73-1
Molecular Formula:C₂₃H₂₅N₃O
Molecular Weight:359.471
Hs Code.:

Synonyms:2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

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Chemical Property of 2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

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Technology Process of 2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

There total 1 articles about 2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 603-76-9
1-methylindole

: 88056-92-2
(-)-2-cyano-6-phenyloxazolopiperidine

: 854045-73-1
2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

Guidance literature:: With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -20 - 20 ℃;
DOI:10.1021/ol047408b

Reference yield:

: 854045-73-1
2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

: 875153-97-2
N-[2-(1-methyl-1H-indol-2-yl)-azepan-3-yl]-2-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / diisopropyl ether / 24 h / Heating

2: 1.76 g / H₂; aq. HCl / Pd/C / methanol / 48 h / 20 °C / pH 2

3: 50 percent / NaHCO₃ / tetrahydrofuran / 20 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; di-isopropyl ether;
DOI:10.1021/ol047408b

Reference yield:

: 854045-73-1
2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

: 10-(1-methyl-1H-indol-2-yl)-7-(2-nitrobenzenesulfonyl)-1,7-diazabicyclo[4.3.1]decan-9-one

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / diisopropyl ether / 24 h / Heating

2: 1.76 g / H₂; aq. HCl / Pd/C / methanol / 48 h / 20 °C / pH 2

3: 50 percent / NaHCO₃ / tetrahydrofuran / 20 h / 0 °C

4: 70 percent / K₂CO₃ / acetonitrile / 24 h / 20 °C

5: 50 percent / K₂CO₃; KI / acetonitrile / 24 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; di-isopropyl ether; acetonitrile;
DOI:10.1021/ol047408b