N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide
CAS No.:854045-81-1
Molecular Formula:C₂₃H₂₅ClN₄O₅S
Molecular Weight:504.994
Hs Code.:

Synonyms:N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide

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Chemical Property of N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide

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Technology Process of N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide

There total 6 articles about N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 875153-97-2
N-[2-(1-methyl-1H-indol-2-yl)-azepan-3-yl]-2-nitro-benzenesulfonamide

: 79-04-9
chloroacetyl chloride

: 854045-81-1
N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1021/ol047408b

Reference yield:

: (R)-2-[(2S,3S)-3-Amino-2-(1-methyl-1H-indol-2-yl)-azepan-1-yl]-2-phenyl-ethanol

: 854045-81-1
N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.76 g / H₂; aq. HCl / Pd/C / methanol / 48 h / 20 °C / pH 2

2: 50 percent / NaHCO₃ / tetrahydrofuran / 20 h / 0 °C

3: 70 percent / K₂CO₃ / acetonitrile / 24 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ol047408b

Reference yield:

: 854045-73-1
2-[7-(1-methyl-1H-indol-2-yl)-6,8-diazabicyclo[3.2.1]oct-6-en-8-yl]-2-phenylethanol

: 854045-81-1
N-[1-(2-chloroacetyl)-2-(1-methyl-1H-indol-2-yl)azepan-3-yl]-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / diisopropyl ether / 24 h / Heating

2: 1.76 g / H₂; aq. HCl / Pd/C / methanol / 48 h / 20 °C / pH 2

3: 50 percent / NaHCO₃ / tetrahydrofuran / 20 h / 0 °C

4: 70 percent / K₂CO₃ / acetonitrile / 24 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; di-isopropyl ether; acetonitrile;
DOI:10.1021/ol047408b