1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea

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Chemical Name:1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea
CAS No.:1114065-54-1
Molecular Formula:C₂₈H₂₈F₃N₃O₃
Molecular Weight:511.544
Hs Code.:

Synonyms:1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea

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Chemical Property of 1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea

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Technology Process of 1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea

There total 10 articles about 1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1114065-45-0
(R)-6-(2-aminoethyl)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one

: 530-62-1
1,1'-carbonyldiimidazole

: 74-89-5
methylamine

: 1114065-54-1
1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea

Guidance literature:: 1,1'-carbonyldiimidazole; methylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

(R)-6-(2-aminoethyl)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one; In dichloromethane; at 20 ℃;

Reference yield: 12.0%

: 1321599-84-1
(R)-6-(2-aminoethyl)-3-((S)-1-(2',4'-difluorobiphenyl-4-ylethyl)-6-(4-fluorophenyl))-1,3-oxazinan-2-one trifluoroacetate

: 74-89-5
methylamine

: 1114065-54-1
1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea

Guidance literature:: methylamine; With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

(R)-6-(2-aminoethyl)-3-((S)-1-(2',4'-difluorobiphenyl-4-ylethyl)-6-(4-fluorophenyl))-1,3-oxazinan-2-one trifluoroacetate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm2005354

Reference yield:

: 1110642-14-2
(S)-6-allyl-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one

: 1114065-54-1
1-(2-((R)-3-((S)-1-(2',4'-difluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl)ethyl)-3-methylurea

Guidance literature:: Multi-step reaction with 6 steps

1.1: ozone / dichloromethane / -78 °C

2.1: sodium tetrahydroborate / dichloromethane / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 16 h / Heating

5.1: triphenylphosphine / tetrahydrofuran; water / 20 °C / Reflux

6.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

6.2: 20 °C

With sodium tetrahydroborate; sodium azide; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2005354