3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one

Base Information

Chemical Name:3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one
CAS No.:1513857-72-1
Molecular Formula:C₁₉H₁₈F₂N₄O₃
Molecular Weight:388.374
Hs Code.:

Synonyms:3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one

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Chemical Property of 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one

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Technology Process of 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one

There total 2 articles about 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1513857-72-1
3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride; pyridine / mineral oil / 1 h / 0 - 20 °C / Inert atmosphere; Large scale

1.2: 20 h / 20 - 25 °C / Large scale

2.1: sec.-butyllithium / cyclohexane / 0.8 h / -75 - -60 °C / Inert atmosphere; Large scale

2.2: 0.5 h / -75 - -65 °C / Large scale

2.3: 20 - 25 °C / Large scale

3.1: water; 2-methoxy-ethanol / 130 °C

4.1: (1S)-10-camphorsulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 48 h / Reflux; Dean-Stark

4.2: 3 h / 50 °C

5.1: tetrahydrofuran / 6 h / 0 - 20 °C

With pyridine; (1S)-10-camphorsulfonic acid; sec.-butyllithium; sodium hydride; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; 2-methoxy-ethanol; cyclohexane; water; mineral oil;

Reference yield:

: 36629-42-2
methyl pentafluorobenzoate

: 1513857-72-1
3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2’:5,6] pyrido[4,3-d]-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 4.5 h / 50 - 65 °C / Large scale

2.1: methanol / 21 h / 20 - 70 °C / Inert atmosphere; Large scale

2.2: 1 h / Large scale

3.1: 75 - 85 °C / Inert atmosphere; Large scale

4.1: palladium on activated charcoal; ammonium formate; acetic acid / ethanol / 50 °C / Large scale

5.1: (1S)-10-camphorsulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 48 h / Reflux; Dean-Stark

5.2: 3 h / 50 °C

6.1: tetrahydrofuran / 6 h / 0 - 20 °C

With methanol; palladium on activated charcoal; (1S)-10-camphorsulfonic acid; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 5,5-dimethyl-1,3-cyclohexadiene; ethanol;