N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

Base Information

Chemical Name:N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide
CAS No.:1361379-09-0
Molecular Formula:C₁₉H₁₂F₂N₂OS₂
Molecular Weight:386.446
Hs Code.:

Synonyms:N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

Suppliers and Price of N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

There total 5 articles about N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361380-50-8
6-methyl-5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))benzothiazole

: 1286538-20-2
(5-bromo(2-thienyl))-N-(2,6-difluorophenyl)carboxamide

: 1361379-09-0
N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 110 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 31555-60-9
5-bromothiophene-2-carbonyl chloride

: 1361379-09-0
N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 7311-63-9
5-bromothiophene-2-carboxylic acid

: 1361379-09-0
N-(2,6-difluorophenyl)[5-(6-methylbenzothiazol-5-yl)(2-thienyl)]carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With oxalyl dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;