diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine

Base Information

Chemical Name:diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine
CAS No.:1330633-14-1
Molecular Formula:C₂₁H₂₉ClN₅O₅P
Molecular Weight:497.919
Hs Code.:

Synonyms:diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine

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Chemical Property of diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine

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Technology Process of diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine

There total 4 articles about diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1330633-13-0
diethyl 3-(benzyloxy)-2-(2-hydroxyethoxy)propylphosphonate

: 10310-21-1
2-Amino-6-chloropurin

: 1330633-14-1
diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -30 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.045

Reference yield:

: 683-08-9
Diethyl methylphosphonate

: 1330633-14-1
diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - -30 °C / Inert atmosphere

1.3: -30 - 20 °C

2.1: borane-THF / -20 - 20 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

With n-butyllithium; borane-THF; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; hexane; 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.06.045

Reference yield:

: 1330633-12-9
ethyl 2-(1-(benzyloxy)-3-(diethoxyphosphoryl)propan-2-yloxy)acetate

: 1330633-14-1
diethyl 9-[2-(3-benzyloxy-1-phosphonopropan-2-yloxy)ethyl]-2-amino-6-chloropurine

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / -20 - 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

With borane-THF; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.06.045