(2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

Base Information

Chemical Name:(2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide
CAS No.:1584149-66-5
Molecular Formula:C₂₈H₂₉ClF₆N₄O₃
Molecular Weight:619.007
Hs Code.:

Synonyms:(2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

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Chemical Property of (2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

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Technology Process of (2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

There total 8 articles about (2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1584150-53-7
(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

: 1584149-66-5
(2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; isopropyl alcohol; for 1.5h;

Reference yield:

: 64182-61-2
1-chloro-3-fluoro-2-nitrobenzene

: 1584149-66-5
(2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / ethanol / 9 h / 80 °C / Inert atmosphere

2: ammonium chloride; ethanol; iron / water / 1.5 h / 80 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 3 h

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 2 h

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 2 h

7: trifluoroacetic acid / dichloromethane / 2.5 h

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonia / tetrahydrofuran; isopropyl alcohol / 1.5 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; ammonia; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; XPhos; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 1584150-52-6
(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

: 1584149-66-5
(2R,3S)-N-((3S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-2,3-bis-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2.5 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonia / tetrahydrofuran; isopropyl alcohol / 1.5 h

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; isopropyl alcohol;