(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

Base Information

Chemical Name:(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate
CAS No.:1584150-52-6
Molecular Formula:C₃₂H₃₆ClF₆N₃O₄
Molecular Weight:676.099
Hs Code.:

(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

Synonyms:(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

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Chemical Property of (2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

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Technology Process of (2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

There total 6 articles about (2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (2R,3S)-3-(tert-butylcarbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

: 1584150-20-8
(S)-3-amino-9-chloro-5-(3-cyclopropylphenyl)-4,5-dihydro-1H-benzo-[b][1,4]-diazepin-2(3H)-one

: 1584150-52-6
(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 64182-61-2
1-chloro-3-fluoro-2-nitrobenzene

: 1584150-52-6
(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / ethanol / 9 h / 80 °C / Inert atmosphere

2: ammonium chloride; ethanol; iron / water / 1.5 h / 80 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 3 h

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 2 h

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 2 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; iron; potassium carbonate; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; XPhos; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1584150-10-6
(S)-tert-butyl (9-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamate

: 1584150-52-6
(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 2 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; XPhos; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;