(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

Base Information

Chemical Name:(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid
CAS No.:1584150-53-7
Molecular Formula:C₂₈H₂₈ClF₆N₃O₄
Molecular Weight:619.991
Hs Code.:

(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

Synonyms:(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

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Chemical Property of (2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

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Technology Process of (2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

There total 7 articles about (2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1584150-52-6
(2S,3R)-tert-butyl 3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoate

: 1584150-53-7
(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2.5h;

Reference yield:

: 64182-61-2
1-chloro-3-fluoro-2-nitrobenzene

: 1584150-53-7
(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / ethanol / 9 h / 80 °C / Inert atmosphere

2: ammonium chloride; ethanol; iron / water / 1.5 h / 80 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 3 h

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 2 h

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 2 h

7: trifluoroacetic acid / dichloromethane / 2.5 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; iron; potassium carbonate; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; XPhos; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1584150-10-6
(S)-tert-butyl (9-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamate

: 1584150-53-7
(2S,3R)-3-(((S)-6-chloro-1-(3-cyclopropylphenyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]-diazepin-3-yl)carbamoyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; potassium carbonate / tert-butyl alcohol / 80 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 2 h

4: trifluoroacetic acid / dichloromethane / 2.5 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; XPhos; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;