4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

Base Information

Chemical Name:4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine
CAS No.:881902-81-4
Molecular Formula:C₁₉H₂₃ClFN₃O₂Si
Molecular Weight:407.947
Hs Code.:

4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridin-4-yloxy]-3-fluoro-phenylamine

Synonyms:4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

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Chemical Property of 4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

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Technology Process of 4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

There total 7 articles about 4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 881902-80-3
4,6-dichloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 399-96-2
4-amino-2-fluorophenol

: 881902-81-4
4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 2h;
DOI:10.1016/j.tetlet.2006.01.143

Reference yield: 88.0%

: 869335-22-8
6-chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 399-96-2
4-amino-2-fluorophenol

: 881902-81-4
4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 2h;
DOI:10.1016/j.tetlet.2006.01.143

Reference yield:

: 688781-87-5
6-chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine

: 881902-81-4
4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / NaH / tetrahydrofuran / 1 h

2: 88 percent / K₂CO₃ / dimethylsulfoxide / 2 h / 100 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2006.01.143