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1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]is a complex chemical compound with a unique molecular structure. It features a pyrrolopyridine core, which is a fused ring system consisting of a pyrrole and a pyridine. This core is substituted with a chloro-nitro group at the 6th position, and an ethoxymethyl group is attached to the nitrogen atom. Additionally, a trimethylsilyl group is attached to the oxygen atom. 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]may have potential applications in medicinal chemistry due to its interesting structural features, which could be exploited in drug discovery and development. However, more research is needed to fully understand its properties and potential uses.

869335-22-8

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  • 6-CHLORO-4-NITRO-1-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-1H-PYRROLO[2,3-B]PYRIDINE

    Cas No: 869335-22-8

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869335-22-8 Usage

Uses

Used in Medicinal Chemistry:
1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]is used as a chemical compound in medicinal chemistry for its unique structural features. Its pyrrolopyridine core, chloro-nitro substitution, and ethoxymethyl and trimethylsilyl groups may offer potential applications in drug discovery and development. Further research is required to explore its properties and potential uses in this field.

Check Digit Verification of cas no

The CAS Registry Mumber 869335-22-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,9,3,3 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 869335-22:
(8*8)+(7*6)+(6*9)+(5*3)+(4*3)+(3*5)+(2*2)+(1*2)=208
208 % 10 = 8
So 869335-22-8 is a valid CAS Registry Number.

869335-22-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(6-chloro-4-nitropyrrolo[2,3-b]pyridin-1-yl)methoxy]ethyl-trimethylsilane

1.2 Other means of identification

Product number -
Other names 6-Chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:869335-22-8 SDS

869335-22-8Relevant articles and documents

AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS

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Page/Page column 40; 42, (2019/07/13)

The invention relates to compounds of formula I inhibiting Rho Kinase that are tyrosine analogues derivatives, processes of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS

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Page/Page column 39; 40, (2020/01/08)

The invention relates to compounds of formula (I) inhibiting Rho Kinase that are azaindole derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof Particularly the compounds of the inventio

TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS

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Paragraph 0446-0447; 0852-0854, (2018/08/20)

Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Improved synthesis of the selective rho-kinase inhibitor 6-chloro-n4-{3,5-difluoro-4-[(3-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl} pyrimidin-2,4-diamine

Schirok, Hartmut,Paulsen, Holger,Kroh, Walter,Chen, Gang,Gao, Ping

scheme or table, p. 168 - 173 (2010/04/29)

A highly potent and selective Rho-kinase inhibitor containing a 7-azaindole moiety has been developed at Bayer Schering Pharma. Herein we disclose details of a significantly improved synthesis of the compound in 8.2% overall yield. Key aspects include cost and safety considerations and the uncommon use of a trifluoromethyl group with controllable reactivity as a masked methyl group.

Substituted Phenylamino-Pyrimidines

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, (2008/12/04)

The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.

Efficient synthesis of 4-O- and C-substituted-7-azaindoles

Figueroa-Pérez, Santiago,Bennabi, Samir,Schirok, Hartmut,Thutewohl, Michael

, p. 2069 - 2072 (2007/10/03)

6-Chloro-4-nitro- and 4,6-dichloro-1H-pyrrolo[2,3-b]pyridine are versatile building blocks that allow the synthesis of 4-substituted 7-azaindole derivatives by simple nucleophilic displacement of the 4-substituent. Herein, we report on their reaction with

SUBSTITUTED PHENYLAMINO-PYRIMIDINES

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Page/Page column 29, (2010/02/14)

The invention relates to substituted phenylamino-pyrimidines, to a method for their production and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular for the treatment of cardiovascular diseases.

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