869335-22-8Relevant articles and documents
AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS
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Page/Page column 40; 42, (2019/07/13)
The invention relates to compounds of formula I inhibiting Rho Kinase that are tyrosine analogues derivatives, processes of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS
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Page/Page column 39; 40, (2020/01/08)
The invention relates to compounds of formula (I) inhibiting Rho Kinase that are azaindole derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof Particularly the compounds of the inventio
TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS
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Paragraph 0446-0447; 0852-0854, (2018/08/20)
Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Improved synthesis of the selective rho-kinase inhibitor 6-chloro-n4-{3,5-difluoro-4-[(3-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl} pyrimidin-2,4-diamine
Schirok, Hartmut,Paulsen, Holger,Kroh, Walter,Chen, Gang,Gao, Ping
scheme or table, p. 168 - 173 (2010/04/29)
A highly potent and selective Rho-kinase inhibitor containing a 7-azaindole moiety has been developed at Bayer Schering Pharma. Herein we disclose details of a significantly improved synthesis of the compound in 8.2% overall yield. Key aspects include cost and safety considerations and the uncommon use of a trifluoromethyl group with controllable reactivity as a masked methyl group.
Substituted Phenylamino-Pyrimidines
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, (2008/12/04)
The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
Efficient synthesis of 4-O- and C-substituted-7-azaindoles
Figueroa-Pérez, Santiago,Bennabi, Samir,Schirok, Hartmut,Thutewohl, Michael
, p. 2069 - 2072 (2007/10/03)
6-Chloro-4-nitro- and 4,6-dichloro-1H-pyrrolo[2,3-b]pyridine are versatile building blocks that allow the synthesis of 4-substituted 7-azaindole derivatives by simple nucleophilic displacement of the 4-substituent. Herein, we report on their reaction with
SUBSTITUTED PHENYLAMINO-PYRIMIDINES
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Page/Page column 29, (2010/02/14)
The invention relates to substituted phenylamino-pyrimidines, to a method for their production and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular for the treatment of cardiovascular diseases.