2-oxo-1-phenylbutylphosphonate de diethyle

Base Information

• Chemical Name: 2-oxo-1-phenylbutylphosphonate de diethyle
• CAS No.: 109632-31-7
• Molecular Formula: C₁₄H₂₁O₄P
• Molecular Weight: 284.292
• Mol file: 109632-31-7.mol

Synonyms:2-oxo-1-phenylbutylphosphonate de diethyle

Chemical Property of 2-oxo-1-phenylbutylphosphonate de diethyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-oxo-1-phenylbutylphosphonate de diethyle

There total 8 articles about 2-oxo-1-phenylbutylphosphonate de diethyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyllithium (811-49-4) + (Chlorocarbonyl-phenyl-methyl)-phosphonic acid diethyl ester (53615-31-9) → 2-oxo-1-phenylbutylphosphonate de diethyle (109632-31-7)

Guidance literature:

With copper(l) iodide; dimethylsulfide; In tetrahydrofuran; diethyl ether; 1.) from -78 deg C to -45 deg C; 2.) -45 deg C, 2.5 h;

Reference yield: 94.0%

(Chlorocarbonyl-phenyl-methyl)-phosphonic acid diethyl ester (53615-31-9) → 2-oxo-1-phenylbutylphosphonate de diethyle (109632-31-7)

Guidance literature:

In tetrahydrofuran; diethyl ether; -78 deg C to -40 deg C; -40 deg C, 90 min;

DOI:10.1055/s-1986-31739

Reference yield: 81.0%

iodobenzene (591-50-4) + diethyl (2-oxobutyl)phosphonate (1067-73-8) → 2-oxo-1-phenylbutylphosphonate de diethyle (109632-31-7)

Guidance literature:

With copper(l) iodide; caesium carbonate; L-proline; In dimethyl sulfoxide; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201100605

upstream raw materials:

phosphonic acid diethyl ester

ethyllithium

(Chlorocarbonyl-phenyl-methyl)-phosphonic acid diethyl ester

2-Nitro-1-phenyl-1-butene

Downstream raw materials:

O,O-diethyl ethyl-1 phenyl-2 ethenyl-1,2 phosphonate