53615-31-9Relevant academic research and scientific papers
A Facile and General, One-pot Synthesis of 2-Oxoalkane Phosphonates from Diethylphosphonocarboxylic Acid Chlorides and Organometallic Reagents
Coutrot, Philippe,Ghribi, Abdellaziz
, p. 661 - 664 (1986)
An efficient and general method for the preparation of 2-oxoalkane phosphonates 2 is described.Diethylphosphono-2-alkanoyl chlorides are used to introduce directly the 2-oxophosphonate 1-substituted synthons on Grignard or cuprate reagents.
SYNTHESE DE PEPTIDES MODIFIES INCORPORANT UN MOTIF PHOSPHORE N OU C TERMINAL
Coutrot, Ph.,Grison, C.,Charbonnier-Gerardin, C.
, p. 9841 - 9868 (2007/10/02)
A general route to phosphopeptides with a 2-oxoalkylphosphonate moiety at the terminal N-amino group or with a 1-aminoalkylphosphonate moiety at the terminal C-carboxyl group is described.The method allows the preparation of various phosphopeptides with an α-alkylated carbon atom on the P-C bond from the very available dialkylpohosphonoalcanoic acids as starting products.
