tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate

Base Information

Chemical Name:tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate
CAS No.:288318-38-7
Molecular Formula:C₁₈H₂₅NO₅S
Molecular Weight:367.466
Hs Code.:

Synonyms:tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate

Chemical Property:

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Technology Process of tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate

There total 4 articles about tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 105-36-2
ethyl bromoacetate

: 73252-35-4
N-benzoyl-D-cysteine tert-butyl ester

: 288318-38-7
tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate

Guidance literature:: With sodium methylate; In methanol; for 1h; Heating;
DOI:10.1021/jo000116d

Reference yield:

: 62574-13-4,85806-66-2
(2S,2'S)-di-tert-butyl 3,3'-disulfanediylbis(2-aminopropanoate)

: 288318-38-7
tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / pyridine / CH₂Cl₂ / 15 h / 0 - 20 °C

2: 70 percent / NaBH₄ / ethanol / 2 h / 25 °C

3: 86 percent / NaOCH₃ / methanol / 1 h / Heating

With pyridine; sodium tetrahydroborate; sodium methylate; In methanol; ethanol; dichloromethane; 1: Acylation / 2: reductive cleavage / 3: Alkylation;
DOI:10.1021/jo000116d

Reference yield:

: 98-88-4
benzoyl chloride

: 288318-38-7
tert-butyl (2S)-2-benzoylamino-3-{[(1-ethoxycarbonyl)methyl]thio}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / pyridine / CH₂Cl₂ / 15 h / 0 - 20 °C

2: 70 percent / NaBH₄ / ethanol / 2 h / 25 °C

3: 86 percent / NaOCH₃ / methanol / 1 h / Heating

With pyridine; sodium tetrahydroborate; sodium methylate; In methanol; ethanol; dichloromethane; 1: Acylation / 2: reductive cleavage / 3: Alkylation;
DOI:10.1021/jo000116d