Methyl 3-hydroxy-2,3-diphenylpropanoate

Base Information

• Chemical Name: Methyl 3-hydroxy-2,3-diphenylpropanoate
• CAS No.: 93434-58-3
• Molecular Formula: C16H16 O3
• Molecular Weight: 256.2964
• NSC Number: 41430
• DSSTox Substance ID: DTXSID70285342
• Nikkaji Number: J364.261E
• Mol file: 93434-58-3.mol

Synonyms:93434-58-3;methyl 3-hydroxy-2,3-diphenylpropanoate;NSC41430;DTXSID70285342;NSC-41430

Chemical Property of Methyl 3-hydroxy-2,3-diphenylpropanoate

Chemical Property:

• Vapor Pressure: 6.58E-07mmHg at 25°C
• Boiling Point: 393.8°Cat760mmHg
• Flash Point: 163.3°C
• Density: 1.173g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 256.109944368
• Heavy Atom Count: 19
• Complexity: 278

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(C1=CC=CC=C1)C(C2=CC=CC=C2)O

Technology Process of Methyl 3-hydroxy-2,3-diphenylpropanoate

There total 34 articles about Methyl 3-hydroxy-2,3-diphenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzaldehyde (100-52-7) + benzeneacetic acid methyl ester (101-41-7) → α-benzenessigsaeure-methylester (17226-93-6,17226-94-7,58769-52-1,58769-53-2,93434-58-3,120851-53-8,139628-23-2)

Guidance literature:

benzeneacetic acid methyl ester; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

benzaldehyde; In dichloromethane; at -78 ℃; for 3h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol301782s

Reference yield: 91.0%

3-Oxo-2,3-diphenylpropenoic acid methyl ester (54108-62-2) → (2R,3R)-und (2S,3S)-3-Hydroxy-2,3-diphenylpropansaeure-methylester (17226-93-6,17226-94-7,58769-52-1,58769-53-2,93434-58-3,120851-53-8,139628-23-2)

Guidance literature:

With zinc(II) tetrahydroborate; zinc(II) chloride; In diethyl ether; at -15 ℃; for 5h;

Reference yield: 88.0%

(4S,5R)-3-Methoxy-4,5-diphenyl-4,5-dihydro-isoxazole (110164-94-8) → methyl 3-hydroxy-2,3-diphenylpropionate (93434-58-3)

Guidance literature:

With hydrogen; boric acid; nickel;

DOI:10.1016/S0040-4039(00)85028-5

upstream raw materials:

3-Oxo-2,3-diphenylpropenoic acid methyl ester

(2RS,3RS)-3-hydroxy-2,3-diphenyl-propionic acid

N,N-dimethyl-formamide dimethyl acetal

methanol