(S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone

Base Information

Chemical Name:(S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone
CAS No.:1437716-43-2
Molecular Formula:C₂₀H₂₈ClN₃O₄
Molecular Weight:409.913
Hs Code.:

Synonyms:(S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone

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Chemical Property of (S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone

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Technology Process of (S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone

There total 6 articles about (S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (S)-N-(2-(2-chloro-5-methoxy-4-nitrophen)ethyl)-1-(piperidin-4-yl)ethanamine hydrochloride

: 1759-53-1
cyclopropanecarboxylic acid

: 1437716-43-2
(S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone

Guidance literature:: cyclopropanecarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

(S)-N-(2-(2-chloro-5-methoxy-4-nitrophen)ethyl)-1-(piperidin-4-yl)ethanamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1437716-26-1
(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

: 1437716-43-2
(S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2.2: 16 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1027833-17-5
1-bromo-2-chloro-5-fluoro-4-nitrobenzene

: 1437716-43-2
(S)-(4-(1-(2-chloro-5-methoxy-4-nitrophenethylamino)ethyl)piperidin-1-yl)(cyclopropyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / propan-1-ol / 4 h / Reflux

3.1: quinoline / isopropyl alcohol / 56 h / Reflux

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

5.2: 16 h / 20 °C

With quinoline; hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; propan-1-ol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;