(1'R,2S)-1--2-methylpyrrolidine

Base Information

Chemical Name:(1'R,2S)-1--2-methylpyrrolidine
CAS No.:135324-62-8
Molecular Formula:C₁₆H₂₆N₂O
Molecular Weight:262.395
Hs Code.:

(1'R,2S)-1-<N-(2-Hydroxy-1-phenylethyl)-N-isopropylamino>-2-methylpyrrolidine

Synonyms:(1'R,2S)-1--2-methylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'R,2S)-1--2-methylpyrrolidine

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Technology Process of (1'R,2S)-1--2-methylpyrrolidine

There total 4 articles about (1'R,2S)-1--2-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 75-16-1
methylmagnesium bromide

: 135324-40-2,135414-48-1
7-Isopropyl-6-phenyl-4-oxa-7,7a-diazaperhydroindan

: 135324-62-8
(1'R,2S)-1--2-methylpyrrolidine

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 12h;
DOI:10.1248/cpb.39.836

Reference yield:

: 112211-92-4
(R)-N-(2-Hydroxy-1-phenylethyl)-N-isopropylamine

: 135324-62-8
(1'R,2S)-1--2-methylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: NaNO₂, HOAc / H₂O / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / Heating

3: 1) MgSO₄, 2) K₂CO₃ / 1) CH₂Cl₂, rt, 2) benzene, reflux

4: 81 percent / tetrahydrofuran; diethyl ether / 12 h / 0 °C

With lithium aluminium tetrahydride; magnesium sulfate; potassium carbonate; acetic acid; sodium nitrite; In tetrahydrofuran; diethyl ether; water;
DOI:10.1248/cpb.39.836

Reference yield:

: 135324-38-8
(R)-N-(2-Hydroxy-1-phenylethyl)-N-isopropylhydrazine

: 135324-62-8
(1'R,2S)-1--2-methylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) MgSO₄, 2) K₂CO₃ / 1) CH₂Cl₂, rt, 2) benzene, reflux

2: 81 percent / tetrahydrofuran; diethyl ether / 12 h / 0 °C

With magnesium sulfate; potassium carbonate; In tetrahydrofuran; diethyl ether;
DOI:10.1248/cpb.39.836