N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine

Base Information

• Chemical Name: N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine
• CAS No.: 848186-81-2
• Molecular Formula: C₁₆H₂₈ClNOSi
• Molecular Weight: 313.943
• Mol file: 848186-81-2.mol

Synonyms:N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine

Chemical Property of N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine

There total 4 articles about N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-5-phenyl-1,3-oxazolidine-2-one (186343-35-1) → N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine (848186-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / aq. NaOH / ethanol / Heating

2: imidazole

3: K₂CO₃; 18-crown-6 / Heating

With 1H-imidazole; sodium hydroxide; 18-crown-6 ether; potassium carbonate; In ethanol;

DOI:10.1016/j.bmcl.2004.11.054

Reference yield:

(S)-2-Amino-1-phenyl-1-ethanol (56613-81-1,1936-63-6) → N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine (848186-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole

2: K₂CO₃; 18-crown-6 / Heating

With 1H-imidazole; 18-crown-6 ether; potassium carbonate;

DOI:10.1016/j.bmcl.2004.11.054

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine (848186-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole

2: K₂CO₃; 18-crown-6 / Heating

With 1H-imidazole; 18-crown-6 ether; potassium carbonate;

DOI:10.1016/j.bmcl.2004.11.054

upstream raw materials:

1,2-dichloro-ethane

(S)-2-((tert-butyldimethylsilyl)oxy)-2-phenylethanamine

(S)-2-Amino-1-phenyl-1-ethanol

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-(2-chloroethylamino)-1-phenyl-1-ethanol

Levamisole

(S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine